A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further...

Full description

Bibliographic Details
Main Authors:	van Heel, D, Franke, L, Hunt, K, Gwilliam, R, Zhernakova, A, Inouye, M, Wapenaar, M, Barnardo, M, Bethel, G, Holmes, G, Feighery, C, Jewell, D, Kelleher, D, Kumar, P, Travis, S, Walters, JR, Sanders, D, Howdle, P, Swift, J, Playford, R, McLaren, WM, Mearin, M, Mulder, C, McManus, R, McGinnis, R
Format:	Journal article
Language:	English
Published:	2007

Similar Items

Celiac disease.
by: Jewell, D
Published: (2000)

Il-23r is a major determinant of ankylosing spondylitis risk - The tasc study
by: Reveille, J, et al.
Published: (2007)

Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.
by: Tye-Din, J, et al.
Published: (2010)

FINE MAPPING OF THE IL-2/IL-21 AND IL2RA LOCI IN PRIMARY SCLEROSING CHOLANGITIS
by: Srivastava, B, et al.
Published: (2012)

Denis Diderot, 'Est-il bon? Est-il méchant?'
by: Diderot, D
Published: (2017)

FINE MAPPING OF THE IL-2/IL-21 AND IL2RA LOCI IN PRIMARY SCLEROSING CHOLANGITIS
by: Srivastava, B, et al.
Published: (2012)

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.
by: Doe, C, et al.
Published: (2010)

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.
by: Uhlig, H, et al.
Published: (2006)

Inhibition of cell-mediated immunity by IL4 and IL10.
by: Powrie, F, et al.
Published: (1993)

Regulation of expression of human IL-1 alpha and IL-1 beta genes.
by: Turner, M, et al.
Published: (1989)

Regulation of expression of human IL-1α and IL-1β genes
by: Turner, M, et al.
Published: (1989)

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
by: Combarros, O, et al.
Published: (2009)

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
by: Uhlig, H, et al.
Published: (2007)

Modulating effects of IL-4, IL-10 AND IL-13 on the course of Plasmodium berghei malaria infection in mice
by: Chin, V. K., et al.
Published: (2021)

IL-2 and IL-15 signaling complexes: different but the same.
by: Ikemizu, S, et al.
Published: (2012)

Locality in A-movement
by: McGinnis, Martha
Published: (2007)

Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis.
by: Sonderegger, I, et al.
Published: (2006)

Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1 alpha and IL-1 receptor antagonist.
by: Phillips, W, et al.
Published: (1995)

Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region.
by: Koch, O, et al.
Published: (2005)

COOPERATION BETWEEN IL-4 AND IL-10 RESULTS IN INHIBITION OF DTH RESPONSES
by: Powrie, F, et al.
Published: (1993)

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
by: Salimi, M, et al.
Published: (2013)

IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
by: Cohen, S, et al.
Published: (1994)

Crystal structure of IL-15/IL-15R alpha complex
by: Chirifu, M, et al.
Published: (2007)

IL-12 and IL-18 are both required for normal bone remodelling and normal trabecular bone mass.
by: Sims, N, et al.
Published: (2003)

IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2.
by: van Den Broek, M, et al.
Published: (2000)

IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.
by: Horwood, N, et al.
Published: (2001)

The development of colitis in Il10−/− mice is dependent on IL-22
by: Gunasekera, Dilini C, et al.
Published: (2021)

The development of colitis in Il10−/− mice is dependent on IL-22
by: Gunasekera, Dilini C., et al.
Published: (2022)

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23
by: Aschenbrenner, D, et al.
Published: (2019)

Analysis of carbohydrates by GLC and MS/
by: Bies, David, et al.
Published: (1989)

IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.
by: Tzartos, J, et al.
Published: (2011)

The IL23 axis plays a key role in the pathogenesis of IBD.
by: McGovern, D, et al.
Published: (2007)

Bartolo in tipografia: il Quattrocento
by: Panzanelli Fratoni, M
Published: (2018)

IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
by: Krueger, JG, et al.
Published: (2024)

Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
by: Aschenbrenner, D, et al.
Published: (2020)

Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes
by: Arneja, Abhinav
Published: (2013)

The role of the IL23/IL17 pathway in inflammatory bowel disease
by: Geremia, A
Published: (2011)

Thariqat-ul-Lamsi fil Alat-il-Katibat-il-Arabiyah/
by: Ridwan, Ahmad Mahmud
Published: (1962)

IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
by: Peng, Judy C., et al.
Published: (2006)

Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice.
by: Guler, R, et al.
Published: (2011)