2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca2+-permeable non19 selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological signals, such as reactive oxygen species or genotoxic stress result in...

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Bibliographic Details
Main Authors: Fliegert, R, Bauche, A, Pérez, A, Watt, J, Rozewitz, M, Winzer, R, Janus, M, Gu, F, Rosche, A, Harneit, A, Flato, M, Moreau, C, Kirchberger, T, Wolters, V, Potter, B, Guse, A
Format: Journal article
Published: Nature Publishing Group 2017

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