Regulation of autophagy by ATF4 in response to severe hypoxia.

Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we ha...

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Bibliographic Details
Main Authors: Rzymski, T, Milani, M, Pike, L, Buffa, F, Mellor, H, Winchester, L, Pires, I, Hammond, E, Ragoussis, I, Harris, A
Format: Journal article
Language:English
Published: 2010