Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities
Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac diseases, mutations, and drug action. However, the pro-arrhythmic mechanisms in PCs are not entirely understood, particularly in humans, as most investigations are conducted in animals. The aims of this study are to...
Main Authors: | Trovato, C, Passini, E, Nagy, N, Varro, A, Abi-Gerges, N, Severi, S, Rodriguez, B |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Elsevier
2020
|
Similar Items
-
P511 In silico trials in human ventricular and purkinje cell models predict safety and efficacy of 10 antiarrhythmic drugs
by: Trovato, C, et al.
Published: (2017) -
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.
by: Passini, E, et al.
Published: (2015) -
Computational framework for multiscale investigation of pro-arrhythmic mechanisms in the human cardiac Purkinje system
by: Trovato, C
Published: (2020) -
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction
by: Cristian Trovato, et al.
Published: (2022-10-01) -
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
by: Passini, E, et al.
Published: (2017)