Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities
Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac diseases, mutations, and drug action. However, the pro-arrhythmic mechanisms in PCs are not entirely understood, particularly in humans, as most investigations are conducted in animals. The aims of this study are to...
Hlavní autoři: | Trovato, C, Passini, E, Nagy, N, Varro, A, Abi-Gerges, N, Severi, S, Rodriguez, B |
---|---|
Médium: | Journal article |
Jazyk: | English |
Vydáno: |
Elsevier
2020
|
Podobné jednotky
-
P511 In silico trials in human ventricular and purkinje cell models predict safety and efficacy of 10 antiarrhythmic drugs
Autor: Trovato, C, a další
Vydáno: (2017) -
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.
Autor: Passini, E, a další
Vydáno: (2015) -
Computational framework for multiscale investigation of pro-arrhythmic mechanisms in the human cardiac Purkinje system
Autor: Trovato, C
Vydáno: (2020) -
In silico investigation of pro-arrhythmic effects of azithromycin on the human ventricle
Autor: Yizhou Liu, a další
Vydáno: (2021-09-01) -
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
Autor: Passini, E, a další
Vydáno: (2017)