Survivin in solid tumors: rationale for development of inhibitors.
Survivin is a 16.5 kDa protein that functions to inhibit apoptosis, promote proliferation, and enhance invasion. Absent in most adult tissues, survivin is selectively upregulated in many human tumors, where its overexpression correlates with poor outcome and treatment resistance. Consequently, survi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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