Survivin in solid tumors: rationale for development of inhibitors.
Survivin is a 16.5 kDa protein that functions to inhibit apoptosis, promote proliferation, and enhance invasion. Absent in most adult tissues, survivin is selectively upregulated in many human tumors, where its overexpression correlates with poor outcome and treatment resistance. Consequently, survi...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1797104307403751424 |
|---|---|
| author | Church, D Talbot, D |
| author_facet | Church, D Talbot, D |
| author_sort | Church, D |
| collection | OXFORD |
| description | Survivin is a 16.5 kDa protein that functions to inhibit apoptosis, promote proliferation, and enhance invasion. Absent in most adult tissues, survivin is selectively upregulated in many human tumors, where its overexpression correlates with poor outcome and treatment resistance. Consequently, survivin is a promising target for cancer therapy. Preclinical data demonstrate that survivin inhibition reduces cell proliferation, increases apoptosis, and sensitises cells to cytotoxic agents and radiotherapy. The pharmacological survivin inhibitors LY2181308 and YM155 have demonstrated acceptable toxicity and evidence of therapeutic efficacy as single agents in early-phase clinical trials. Current efforts seek to define the optimum use of survivin inhibitors in combination with cytotoxic therapies, where it is hoped that preclinical evidence of treatment synergy will translate into improved therapeutic efficacy. Results from these ongoing studies are keenly awaited. |
| first_indexed | 2024-03-07T06:31:56Z |
| format | Journal article |
| id | oxford-uuid:f64651cc-2226-4479-be50-e92e2d9d30c6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:31:56Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:f64651cc-2226-4479-be50-e92e2d9d30c62022-03-27T12:33:58ZSurvivin in solid tumors: rationale for development of inhibitors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f64651cc-2226-4479-be50-e92e2d9d30c6EnglishSymplectic Elements at Oxford2012Church, DTalbot, DSurvivin is a 16.5 kDa protein that functions to inhibit apoptosis, promote proliferation, and enhance invasion. Absent in most adult tissues, survivin is selectively upregulated in many human tumors, where its overexpression correlates with poor outcome and treatment resistance. Consequently, survivin is a promising target for cancer therapy. Preclinical data demonstrate that survivin inhibition reduces cell proliferation, increases apoptosis, and sensitises cells to cytotoxic agents and radiotherapy. The pharmacological survivin inhibitors LY2181308 and YM155 have demonstrated acceptable toxicity and evidence of therapeutic efficacy as single agents in early-phase clinical trials. Current efforts seek to define the optimum use of survivin inhibitors in combination with cytotoxic therapies, where it is hoped that preclinical evidence of treatment synergy will translate into improved therapeutic efficacy. Results from these ongoing studies are keenly awaited. |
| spellingShingle | Church, D Talbot, D Survivin in solid tumors: rationale for development of inhibitors. |
| title | Survivin in solid tumors: rationale for development of inhibitors. |
| title_full | Survivin in solid tumors: rationale for development of inhibitors. |
| title_fullStr | Survivin in solid tumors: rationale for development of inhibitors. |
| title_full_unstemmed | Survivin in solid tumors: rationale for development of inhibitors. |
| title_short | Survivin in solid tumors: rationale for development of inhibitors. |
| title_sort | survivin in solid tumors rationale for development of inhibitors |
| work_keys_str_mv | AT churchd survivininsolidtumorsrationalefordevelopmentofinhibitors AT talbotd survivininsolidtumorsrationalefordevelopmentofinhibitors |