The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signa...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Annual Reviews Inc.
2014
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