Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants

AA disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc-dependent metalloproteinases that are involved in the maintenance of cartilage extracellular matrix (ECM) and are currently considered the major aggrecanases in the development of osteoarth...

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Bibliographic Details
Main Authors: Fowkes, MM, Lim, NH
Other Authors: Apte, SS
Format: Book section
Language:English
Published: Humana Press 2019