Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcIRI

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcIRI

Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcI RI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-Ã.-resolution crystal structure of human...

Podrobná bibliografie
Hlavní autoři:	Holdom, MD, Davies, A, Nettleship, J, Bagby, S, Dhaliwal, B, Girardi, E, Hunt, J, Gould, H, Beavil, A, McDonnell, J, Owens, R, Sutton, B
Médium:	Journal article
Jazyk:	English
Vydáno:	2011

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