Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a multicomponent, nutrient-sensitive protein that is implicated in a wide range of major human diseases. mTORC1 responds to both growth factors and changes in local amino acid levels. Until recently, the intracellular amino acid-sensing mech...
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| 格式: | Journal article |
| 语言: | English |
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2010
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