Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication.

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mam...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Foskolou, IP, Jorgensen, C, Leszczynska, KB, Olcina, MM, Tarhonskaya, H, Haisma, B, D'Angiolella, V, Myers, WK, Domene, C, Flashman, E, Hammond, EM
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: Elsevier 2017