Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication.

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mam...

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Detaylı Bibliyografya
Asıl Yazarlar: Foskolou, IP, Jorgensen, C, Leszczynska, KB, Olcina, MM, Tarhonskaya, H, Haisma, B, D'Angiolella, V, Myers, WK, Domene, C, Flashman, E, Hammond, EM
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2017