Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

BACKGROUND: Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1alpha and -2alpha is a critical event in the pathogenesis of most clear cell renal cell carcinomas (RCC). HIF-1alpha and HIF-2alpha share signif...

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Bibliographic Details
Main Authors: Morris, MR, Hughes, D, Tian, Y, Ricketts, C, Lau, K, Gentle, D, Shuib, S, Serrano-Fernandez, P, Lubinski, J, Wiesener, MS, Pugh, C, Latif, F, Ratcliffe, P, Maher, E
Format: Journal article
Language:English
Published: 2009

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