Tryptophan depletion in normal volunteers produces selective impairments in learning and memory.

The amino-acid L-tryptophan is essential in the synthesis of brain serotonin, and its depletion can lead to a widespread reduction in central serotonergic activity. A placebo-controlled cross-over within-subjects design (n = 12) examined the effects of tryptophan depletion on human cognitive perform...

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Bibliographic Details
Main Authors: Park, S, Coull, J, McShane, R, Young, A, Sahakian, B, Robbins, T, Cowen, P
Format: Journal article
Language:English
Published: 1994