Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses.

PURPOSE: The therapeutic potential of combining the prototype tumor vascular-disrupting agent combretastatin A-4 3-O-phosphate (CA-4-P) with systemic nitric oxide synthase (NOS) inhibition was investigated preclinically. EXPERIMENTAL DESIGN: Vascular response (uptake of (125)I-labeled iodoantipyrine...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: Tozer, G, Prise, V, Lewis, G, Xie, S, Wilson, I, Hill, S
Format: Journal article
Sprog:English
Udgivet: 2009