PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

BACKGROUND: Epidemiologic and genetic evidence links type 2 diabetes, obesity, and cancer. The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growth and metabolic signaling. Germline PTEN mutations cause a cancer-predisposition syndrome, providing an opportunity...

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Bibliographic Details
Main Authors:	Pal, A, Barber, T, Van de Bunt, M, Rudge, SA, Zhang, Q, Lachlan, K, Cooper, N, Linden, H, Levy, J, Wakelam, M, Walker, L, Karpe, F, Gloyn, A
Format:	Journal article
Language:	English
Published:	2012

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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