NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
The transcription factor NF-kappaB is of major importance in the biology of pro-inflammatory cytokines, such as TNF-alpha and IL-1alpha, and thereby is intimately involved in the process of inflammation. Understanding the mechanisms by which NF-kappaB is activated in response to inflammatory stimuli...
Glavni autori: | Smith, C, Andreakos, E, Crawley, J, Brennan, F, Feldmann, M, Foxwell, B |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2001
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