Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions

Although native mass spectrometry is widely applied to monitor chemical or thermal protein denaturation, it is not clear to what extent it can inform about alkali-induced unfolding. Here, we probe the relationship between solution- and gas-phase structures of proteins under alkaline conditions. Nati...

Повний опис

Бібліографічні деталі
Автори: Sahin, C, Österlund, N, Leppert, A, Johansson, J, Marklund, E, Benesch, JLP, Ilag, LL, Allison, TM, Landreh, M
Формат: Journal article
Мова:English
Опубліковано: Royal Society of Chemistry 2021