Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions
Although native mass spectrometry is widely applied to monitor chemical or thermal protein denaturation, it is not clear to what extent it can inform about alkali-induced unfolding. Here, we probe the relationship between solution- and gas-phase structures of proteins under alkaline conditions. Nati...
| Main Authors: | , , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
Royal Society of Chemistry
2021
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