HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C receptors expressed on natural killer and T cell subsets. We show that among 16 common classical HLA class I SP variants, only 6 can be...

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Bibliographic Details
Main Authors:	Lin, Z, Bashirova, AA, Viard, M, Garner, L, Quastel, M, Beiersdorfer, M, Kasprzak, WK, Akdag, M, Yuki, Y, Ojeda, P, Das, S, Andresson, T, Naranbhai, V, Horowitz, A, McMichael, AJ, Hoelzemer, A, Gillespie, GM, Garcia-Beltran, WF, Carrington, M
Format:	Journal article
Language:	English
Published:	Springer Nature 2023

HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

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