Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

HIF (hypoxia-inducible factor) is an alphabeta transcription factor that modulates the hypoxic response in many animals. The cellular abundance and activity of HIF-alpha are regulated by its post-translational hydroxylation. The hydroxylation of HIF is catalysed by PHD (prolyl hydroxylase domain) en...

Bibliográfalaš dieđut
Váldodahkkit:	Lancaster, D, McNeill, L, McDonough, M, Aplin, RT, Hewitson, K, Pugh, C, Ratcliffe, P, Schofield, C
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2004

Geahča maid

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
Dahkki: Banerji, B, et al.
Almmustuhtton: (2005)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
Dahkki: Lancaster, D, et al.
Almmustuhtton: (2004)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Dahkki: Cockman, M, et al.
Almmustuhtton: (2006)

Selective inhibition of factor inhibiting hypoxia-inducible factor.
Dahkki: McDonough, M, et al.
Almmustuhtton: (2005)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Dahkki: Hewitson, K, et al.
Almmustuhtton: (2002)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
Dahkki: Conejo-Garcia, A, et al.
Almmustuhtton: (2005)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
Dahkki: Yang, M, et al.
Almmustuhtton: (2011)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
Dahkki: Hewitson, K, et al.
Almmustuhtton: (2008)

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
Dahkki: McNeill, L, et al.
Almmustuhtton: (2002)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Dahkki: Conejo-Garcia, A, et al.
Almmustuhtton: (2010)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
Dahkki: Elkins, J, et al.
Almmustuhtton: (2003)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
Dahkki: Hewitson, K, et al.
Almmustuhtton: (2007)

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
Dahkki: Coleman, M, et al.
Almmustuhtton: (2007)

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
Dahkki: Webb, J, et al.
Almmustuhtton: (2009)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
Dahkki: Wu, Y, et al.
Almmustuhtton: (2021)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
Dahkki: Stolze, I, et al.
Almmustuhtton: (2004)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
Dahkki: Conejo-Garcia, A, et al.
Almmustuhtton: (2010)

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
Dahkki: Yang, M, et al.
Almmustuhtton: (2013)

Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.
Dahkki: Hewitson, K, et al.
Almmustuhtton: (2004)

Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism
Dahkki: Holliday, J, et al.
Almmustuhtton: (2018)

Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis
Dahkki: Ma, J
Almmustuhtton: (2017)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
Dahkki: Yang, M, et al.
Almmustuhtton: (2011)

Factor-inhibiting HIF (FIH) promotes lung cancer progression
Dahkki: Ana García-del Río, et al.
Almmustuhtton: (2023-10-01)

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
Dahkki: Cockman, M, et al.
Almmustuhtton: (2009)

Fih attenuates the hypoxic tolerance of Megalobrama amblycephala by inhibiting the activity of hypoxia-inducible factor alpha (hif-α)
Dahkki: Jun Li, et al.
Almmustuhtton: (2024-08-01)

The selectivity and inhibition of AlkB.
Dahkki: Welford, R, et al.
Almmustuhtton: (2003)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Dahkki: Chowdhury, R, et al.
Almmustuhtton: (2009)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
Dahkki: Hewitson, K, et al.
Almmustuhtton: (2007)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
Dahkki: McDonough, M, et al.
Almmustuhtton: (2003)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
Dahkki: Pollard, P, et al.
Almmustuhtton: (2008)

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival
Dahkki: Kiriakidis, S, et al.
Almmustuhtton: (2015)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Dahkki: McDonough, M, et al.
Almmustuhtton: (2006)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
Dahkki: Flashman, E, et al.
Almmustuhtton: (2008)

Inhibition of 2-oxoglutarate dependent oxygenases.
Dahkki: Rose, N, et al.
Almmustuhtton: (2011)

Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively
Dahkki: Wang, Y, et al.
Almmustuhtton: (2018)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
Dahkki: Chan, M, et al.
Almmustuhtton: (2016)

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.
Dahkki: Soilleux, E, et al.
Almmustuhtton: (2005)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
Dahkki: McNeill, L, et al.
Almmustuhtton: (2005)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Dahkki: Mole, D, et al.
Almmustuhtton: (2003)

Inhibition of JMJD6 by 2-oxoglutarate mimics
Dahkki: Islam, MS, et al.
Almmustuhtton: (2021)