High-resolution analysis of cis-acting regulatory networks at the α-globin locus.

We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000 kb), the 4C approach provides a com...

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Bibliographic Details
Main Authors: Hughes, J, Lower, K, Dunham, I, Taylor, S, De Gobbi, M, Sloane-Stanley, J, McGowan, S, Ragoussis, J, Vernimmen, D, Gibbons, R, Higgs, D
Format: Journal article
Language:English
Published: 2013