Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation

Biomolecule environments can enhance chemistries with the potential to mediate and modulate self-modification (e.g., self-cleavage). While these enhanced modes are found in certain biomolecules (e.g., RNA ribozymes), it is more rare in proteins. Targeted proteolytic cleavage is vital to physiology,...

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Détails bibliographiques
Auteurs principaux: Mollner, TA, Giltrap, AM, Zeng, Y, Demyanenko, Y, Buchanan, C, Oehlrich, D, Baldwin, AJ, Anthony, DC, Mohammed, S, Davis, BG
Format: Journal article
Langue:English
Publié: American Association for the Advancement of Science 2022