Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.

Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.

Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascades are key signalling pathways interacting with each other to regulate cell growth and tumourigenesis. We have previously shown B-Raf and Akt overexpression and/or overactivation in pituitary adenomas...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Dworakowska, D, Wlodek, E, Leontiou, C, Igreja, S, Cakir, M, Teng, M, Prodromou, N, Góth, M, Grozinsky-Glasberg, S, Gueorguiev, M, Kola, B, Korbonits, M, Grossman, AB
Formato:	Journal article
Idioma:	English
Publicado em:	2009

Registros relacionados

The role of somatostatin analogues in the treatment of neuroendocrine tumours.
por: Grozinsky-Glasberg, S, et al.
Publicado em: (2008)

The pathology of pituitary adenomas from a clinical perspective.
por: Dworakowska, D, et al.
Publicado em: (2011)

Novel molecular aspects of pituitary adenomas.
por: Hubina, E, et al.
Publicado em: (2005)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
por: Ufuk Degirmenci, et al.
Publicado em: (2020-01-01)

The pathophysiology of pituitary adenomas.
por: Dworakowska, D, et al.
Publicado em: (2009)

PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation
por: Xiaojuan Wang, et al.
Publicado em: (2020-08-01)

Direct Targeting of the Raf-MEK-ERK Signaling Cascade Inhibits Neuroblastoma Growth
por: Rameswari Chilamakuri, et al.
Publicado em: (2022-09-01)

Detection of activating mutations in RAS/RAF/MEK/ERK and JAK/STAT signaling pathways
por: K. I. Zarubina, et al.
Publicado em: (2020-09-01)

Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor
por: Emma Tabe Eko Niba, et al.
Publicado em: (2013-06-01)

Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms.
por: Grozinsky-Glasberg, S, et al.
Publicado em: (2008)

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
por: Zerbib, J, et al.
Publicado em: (2024)

Combination therapies to inhibit the RAF/MEK/ERK pathway in melanoma: we are not done yet.
por: Grant A. McArthur
Publicado em: (2015-07-01)

Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation
por: Thomas Yul Avery, et al.
Publicado em: (2022-07-01)

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
por: Johanna Zerbib, et al.
Publicado em: (2024-09-01)

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.
por: Sergio Coffa, et al.
Publicado em: (2011-01-01)

Leptin in pituitary adenomas--a novel paracrine regulatory system.
por: Korbonits, M, et al.
Publicado em: (2001)

Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway
por: Guo Chenyun, et al.
Publicado em: (2022-12-01)

Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway
por: Qing Rao, et al.
Publicado em: (2022-05-01)

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
por: Irem Ozkan-Dagliyan, et al.
Publicado em: (2020-06-01)

Macrophage migration inhibitory factor expression is increased in pituitary adenoma cell nuclei.
por: Pyle, M, et al.
Publicado em: (2003)

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia
por: Enrico Tiacci, et al.
Publicado em: (2013-04-01)

Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials
por: Yanlin Song, et al.
Publicado em: (2023-01-01)

Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
por: Ying Zhang, et al.
Publicado em: (2022-03-01)

Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
por: Qingfang Li, et al.
Publicado em: (2022-12-01)

Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation
por: Zayda Fonseca, et al.
Publicado em: (2018-07-01)

Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting
por: Thomas eKnight, et al.
Publicado em: (2014-06-01)

The Pathogenic Role of AIP Mutations - The Importance of the Integration of Clinical, Experimental and Modeling Data on Advising Patients and Their Families with Pituitary Adenoma Predisposition.
por: Trivellin, G, et al.
Publicado em: (2010)

Semen podocarpi extract enhances radiosensitivity in nasopharyngeal carcinoma cells via Raf/MEK/ERK signaling pathway
por: Fan-Yan Zeng, et al.
Publicado em: (2025-02-01)

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy
por: Ichiro Yajima, et al.
Publicado em: (2012-01-01)

CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
por: Zhipeng Yin, et al.
Publicado em: (2024-08-01)

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway.
por: Rongcai Yue, et al.
Publicado em: (2015-01-01)

Prevalence and patterns of mutations in RAS/RAF/MEK/ERK/MAPK signaling pathway in colorectal cancer in North Africa
por: Meryem Jafari, et al.
Publicado em: (2022-11-01)

Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
por: Nilsson Ola, et al.
Publicado em: (2011-01-01)

Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
por: Zhaohu Lin, et al.
Publicado em: (2014-01-01)

Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell Line.
por: Grozinsky-Glasberg, S, et al.
Publicado em: (2008)

Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas.
por: Morris, D, et al.
Publicado em: (2003)

NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP
por: Yi Wen, et al.
Publicado em: (2022-12-01)

MicroRNA-503 Suppresses Oral Mucosal Fibroblast Differentiation by Regulating RAS/RAF/MEK/ERK Signaling Pathway
por: Dada Wen, et al.
Publicado em: (2024-10-01)

TCF19 promotes cell proliferation and tumor formation in lung cancer by activating the Raf/MEK/ERK signaling pathway
por: Yahui Tian, et al.
Publicado em: (2024-07-01)

Nicotine regulates PCSK9 expression in HepG2 cells through Raf/MEK/ERK signaling pathway
por: ZHOU Lin, et al.
Publicado em: (2023-07-01)