Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
Royal Society of Chemistry
2022
|