Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Dysko, A, Baker, YR, McClorey, G, Wood, MJA, Fenner, S, Williams, G, El-Sagheer, A, Brown, T
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Royal Society of Chemistry 2022

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