Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...

Detaylı Bibliyografya
Asıl Yazarlar:	Dysko, A, Baker, YR, McClorey, G, Wood, MJA, Fenner, S, Williams, G, El-Sagheer, A, Brown, T
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Royal Society of Chemistry 2022

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