Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

Runx1 is a transcription factor that plays a key role in determining the proliferative and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence...

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Bibliographic Details
Main Authors: Koth, J, Wang, X, Killen, AC, Stockdale, W, Potts, HG, Jefferson, A, Bonkhofer, F, Riley, P, Patient, R, Göttgens, B, Mommersteeg, M
Format: Journal article
Language:English
Published: Company of Biologists 2020