Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

Runx1 is a transcription factor that plays a key role in determining the proliferative and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence...

Detaylı Bibliyografya
Asıl Yazarlar:	Koth, J, Wang, X, Killen, AC, Stockdale, W, Potts, HG, Jefferson, A, Bonkhofer, F, Riley, P, Patient, R, Göttgens, B, Mommersteeg, M
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Company of Biologists 2020

Benzer Materyaller

Unlocking the secrets of the regenerating fish heart: comparing regenerative models to shed light on successful regeneration
Yazar:: Potts, HG, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration
Yazar:: Helen G. Potts, ve diğerleri
Baskı/Yayın Bilgisi: (2021-01-01)

Identification of novel Runx1 targets involved in HSC development
Yazar:: Bonkhofer, F
Baskı/Yayın Bilgisi: (2017)

High-resolution magnetic resonance imaging of the regenerating adult zebrafish heart
Yazar:: Koth, J, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Talkin’ ‘bout regeneration: new advances in cardiac regeneration using the zebrafish
Yazar:: Smith, KA, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Skeletal muscle regeneration in zebrafish
Yazar:: Pipalia, TG, ve diğerleri
Baskı/Yayın Bilgisi: (2023)

High-Resolution Magnetic Resonance Imaging of the Regenerating Adult Zebrafish Heart
Yazar:: Jana Koth, ve diğerleri
Baskı/Yayın Bilgisi: (2017-06-01)

Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
Yazar:: Chenglu Xiao, ve diğerleri
Baskı/Yayın Bilgisi: (2016-12-01)

Heart regeneration in the Mexican cavefish
Yazar:: Stockdale, W, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration.
Yazar:: Kfir Baruch Umansky, ve diğerleri
Baskı/Yayın Bilgisi: (2015-08-01)

29 Cardio-Omentopexy to Reduce Myocardial Scarring and Promote Regeneration
Yazar:: Stephen Stachnik, ve diğerleri
Baskı/Yayın Bilgisi: (2024-04-01)

9 Cardio-Omentopexy to Reduce Myocardial Scarring and Promote Regeneration
Yazar:: Stephen Stachnik, ve diğerleri
Baskı/Yayın Bilgisi: (2023-04-01)

Investigating the mechanisms underlying myocardial regeneration in the Mexican cavefish
Yazar:: Stockdale, W
Baskı/Yayın Bilgisi: (2021)

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Yazar:: Simoes, FC, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish
Yazar:: Bevan, L, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration
Yazar:: Troy Anderson, ve diğerleri
Baskı/Yayın Bilgisi: (2023-09-01)

Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia
Yazar:: Robyn Lints, ve diğerleri
Baskı/Yayın Bilgisi: (2024-09-01)

Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins.
Yazar:: Lee, Y, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
Yazar:: Bee, T, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration
Yazar:: Kexiao Zheng, ve diğerleri
Baskı/Yayın Bilgisi: (2024-07-01)

A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
Yazar:: Knezevic, K, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration
Yazar:: Subhra P. Hui, ve diğerleri
Baskı/Yayın Bilgisi: (2022-08-01)

Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration
Yazar:: Michka Sharpe, ve diğerleri
Baskı/Yayın Bilgisi: (2022-02-01)

Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration.
Yazar:: Ying Huang, ve diğerleri
Baskı/Yayın Bilgisi: (2013-01-01)

Transforming Growth Factor β drives haemogenic endothelium programming and the transition to haematopoietic stem cells
Yazar:: Monteiro, R, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair
Yazar:: Pipalia, T, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish.
Yazar:: Der-Chih Yang, ve diğerleri
Baskı/Yayın Bilgisi: (2011-01-01)

Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration
Yazar:: de Bakker, DEM, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
Yazar:: Bonkhofer, F, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Correction: Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration
Baskı/Yayın Bilgisi: (2014-01-01)

The developmental origin of heart size and shape differences in Astyanax mexicanus populations
Yazar:: Tang, J, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

Regeneration of Dermis: Scarring and Cells Involved
Yazar:: Alexandra L. Rippa, ve diğerleri
Baskı/Yayın Bilgisi: (2019-06-01)

Functional heterogeneity within the developing zebrafish epicardium
Yazar:: Weinberger, M, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation.
Yazar:: Kristin Schnabel, ve diğerleri
Baskı/Yayın Bilgisi: (2011-04-01)

Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish.
Yazar:: Nicholas B Ang, ve diğerleri
Baskı/Yayın Bilgisi: (2020-01-01)

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche
Yazar:: Fitch, SR, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

The origins and programming of adult and embryonic blood in xenopus and zebrafish.
Yazar:: Patient, R, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.
Yazar:: Nicolas Bonadies, ve diğerleri
Baskı/Yayın Bilgisi: (2015-01-01)

Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes
Yazar:: Shota Suzuki, ve diğerleri
Baskı/Yayın Bilgisi: (2023-12-01)

New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration
Yazar:: Michela Deiana, ve diğerleri
Baskı/Yayın Bilgisi: (2018-11-01)