Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

Runx1 is a transcription factor that plays a key role in determining the proliferative and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence...

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Bibliografiske detaljer
Main Authors:	Koth, J, Wang, X, Killen, AC, Stockdale, W, Potts, HG, Jefferson, A, Bonkhofer, F, Riley, P, Patient, R, Göttgens, B, Mommersteeg, M
Format:	Journal article
Sprog:	English
Udgivet:	Company of Biologists 2020

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af: Bonkhofer, F
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af: Smith, KA, et al.
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af: Pipalia, TG, et al.
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af: Chenglu Xiao, et al.
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af: Stockdale, W, et al.
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af: Kfir Baruch Umansky, et al.
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af: William T. Stockdale, et al.
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af: Stockdale, W
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af: Simoes, FC, et al.
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af: Bevan, L, et al.
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af: Robyn Lints, et al.
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af: Lee, Y, et al.
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af: Bee, T, et al.
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af: Kexiao Zheng, et al.
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A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
af: Knezevic, K, et al.
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af: Monteiro, R, et al.
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af: Subhra P. Hui, et al.
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af: Michka Sharpe, et al.
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af: Ying Huang, et al.
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af: Pipalia, T, et al.
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Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish.
af: Der-Chih Yang, et al.
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af: de Bakker, DEM, et al.
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af: Bonkhofer, F, et al.
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Correction: Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration
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af: Weinberger, M, et al.
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af: Kristin Schnabel, et al.
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af: Nicholas B Ang, et al.
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Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche
af: Fitch, SR, et al.
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The origins and programming of adult and embryonic blood in xenopus and zebrafish.
af: Patient, R, et al.
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The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.
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