Causal associations of adiposity and body fat distribution with coronary heart disease, dtroke dubtypes, and type 2 diabetes mellitus: a Mendelian randomization analysis

The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with card...

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Main Authors: Dale, CE, Fatemifar, G, Palmer, TM, White, J, Prieto-Merino, D, Zabaneh, D, Engmann, JEL, Shah, T, Wong, A, Warren, HR, McLachlan, S, Trompet, S, Moldovan, M, Morris, RW, Sofat, R, Kumari, M, Hyppönen, E, Jefferis, BJ, Gaunt, TR, Ben-Shlomo, Y, Zhou, A, Gentry-Maharaj, A, Ryan, A, Mutsert, R, Noordam, R, Caulfield, MJ, Jukema, JW, Worrall, BB, Munroe, PB, Menon, U, Power, C, Kuh, D, Lawlor, DA, Humphries, SE, Mook-Kanamori, DO, Sattar, N, Kivimaki, M, Price, JF, Smith, G, Dudbridge, F, Hingorani, AD, Holmes, MV, Casas, JP
Format: Journal article
Language:English
Published: American Heart Association 2017