An axonal brake on striatal dopamine output by cholinergic interneurons

Depolarization of axons is necessary for somatic action potentials to trigger axonal neurotransmitter release. We show that striatal cholinergic interneurons (ChIs) and nicotinic receptors (nAChRs) on mouse dopamine axons interrupt this relationship. Following nAChRmediated depolarization, dopamine...

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Detalhes bibliográficos
Main Authors: Zhang, Y-F, Luan, P, Qiao, Q, He, Y, Zatka-Haas, P, Zhang, G, Lin, MZ, Lak, A, Jing, M, Mann, EO, Cragg, SJ
Formato: Journal article
Idioma:English
Publicado em: Springer Nature 2025