MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

MYH associated polyposis is a hereditary syndrome responsible for early colorectal cancer with a distinct genetic pathway from the Familial Adenomatous Polyposis or the Hereditary Non Polyposis Colorectal Cancer syndrome. We have studied a family with three members bearing a biallelic mutation in MY...

Bibliográfalaš dieđut
Váldodahkkit:	Lefevre, J, Colas, C, Coulet, F, Bonilla, C, Mourra, N, Flejou, J, Tiret, E, Bodmer, W, Soubrier, F, Parc, Y
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2010

Geahča maid

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.
Dahkki: Sieber, O, et al.
Almmustuhtton: (2004)

<it>MYH </it>Gene Status in Polish FAP Patients without <it>APC </it>Gene Mutations
Dahkki: Skrzypczak Marzena, et al.
Almmustuhtton: (2006-01-01)

Aggressive gastric cancer in a patient with an APC mutation and a monoallelic MYH mutation
Dahkki: Wise Paul, et al.
Almmustuhtton: (2010-05-01)

Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
Dahkki: Wheeler, J, et al.
Almmustuhtton: (1999)

Characterization of somatic mutations of colorectal tumor in a patient with concurrent APC and MLH1 germline mutations
Dahkki: Yunsheng Cheng, et al.
Almmustuhtton: (2023-11-01)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
Dahkki: Thirlwell, C, et al.
Almmustuhtton: (2007)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.
Dahkki: Lefevre, J, et al.
Almmustuhtton: (2012)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer
Dahkki: Lefevre, J, et al.
Almmustuhtton: (2012)

Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease
Dahkki: Karla L. Otterpohl, et al.
Almmustuhtton: (2020-11-01)

Cigarette Smoke Induces Colorectal Carcinogenesis in Wistar Rats by Decreasing The Expression of APC, MSH2 and MLH1
Dahkki: Dody Novrial, et al.
Almmustuhtton: (2017-04-01)

The ABC of APC.
Dahkki: Fearnhead, N, et al.
Almmustuhtton: (2001)

Intestinal Apc‐inactivation induces HSP25 dependency
Dahkki: Sanne M van Neerven, et al.
Almmustuhtton: (2022-11-01)

Investigation of APC, MLH1 and MSH2 Mutations in Patients with Hereditary Colorectal Carcinoma: A Single Center Experience
Dahkki: Mehmet Buğrahan Düz
Almmustuhtton: (2021-01-01)

Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer.
Dahkki: Vania Myralda Giamour Marbun, et al.
Almmustuhtton: (2022-01-01)

Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer
Dahkki: Vania Myralda Giamour Marbun, et al.
Almmustuhtton: (2022-01-01)

rSNP_Guide-BASED EVALUATION OF SNPs IN PROMOTеRS OF THE HUMAN APC AND MLH1 GENES ASSOCIATED WITH COLON CANCER
Dahkki: D. A. Rasskazov, et al.
Almmustuhtton: (2015-01-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
Dahkki: Bodmer, W
Almmustuhtton: (1999)

EBV-Infection in Cardiac and Non-Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1
Dahkki: Helene Geddert, et al.
Almmustuhtton: (2010-01-01)

Mutations in <it>APC</it>, <it>CTNNB1 </it>and <it>K-ras </it>genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study
Dahkki: de Bruïne Adriaan P, et al.
Almmustuhtton: (2005-12-01)

PHYSICAL MAPPING OF THE APC REGION
Dahkki: Thomas, H, et al.
Almmustuhtton: (1991)

Functional assessment of a novel biallelic MYH3 variation causing CPSKF1B (contractures, pterygia, and spondylocarpotarsal fusion syndrome1B)
Dahkki: Qing‐bing He, et al.
Almmustuhtton: (2024-03-01)

Biallelic inactivation of SDHA results in comorbidity of pediatric recurrent neuroblastoma and gastric stromal tumor
Dahkki: Shen Yang, et al.
Almmustuhtton: (2024-11-01)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers.
Dahkki: Wheeler, J, et al.
Almmustuhtton: (2000)

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
Dahkki: Michele Pelosi, et al.
Almmustuhtton: (2017-12-01)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI plus sporadic colorectal cancers
Dahkki: Wheeler, J, et al.
Almmustuhtton: (2000)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus sporadic RER plus colorectal cancers
Dahkki: Wheeler, J, et al.
Almmustuhtton: (2000)

Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Dahkki: Vid Leko, et al.
Almmustuhtton: (2013-01-01)

MYH9 nephropathy
Dahkki: Taehoon Oh, et al.
Almmustuhtton: (2015-03-01)

A case of MYH7 and MYH9 genes variants with cardiomyopathy and macrothrombocytopenia
Dahkki: Yasuhiro Ikawa, et al.
Almmustuhtton: (2024-02-01)

Nonmuscle myosin 2 proteins encoded by Myh9, Myh10, and Myh14 are uniquely distributed in the tubular segments of murine kidney
Dahkki: Karla L. Otterpohl, et al.
Almmustuhtton: (2017-12-01)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.
Dahkki: Bonilla, C, et al.
Almmustuhtton: (2011)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients
Dahkki: Bonilla, C, et al.
Almmustuhtton: (2015)

APC in the regulation of intestinal crypt fission.
Dahkki: Wasan, H, et al.
Almmustuhtton: (1998)

<it>MSH2 </it>and <it>MLH1 </it>testing
Dahkki: Kurzawski Grzegorz, et al.
Almmustuhtton: (2008-06-01)

Assessing pathogenicity of <it>MLH1 </it>variants by co-expression of human <it>MLH1 </it>and <it>PMS2 </it>genes in yeast
Dahkki: Hudler Petra, et al.
Almmustuhtton: (2009-10-01)

APC mutations are sufficient for the growth of early colorectal adenomas.
Dahkki: Lamlum, H, et al.
Almmustuhtton: (2000)

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
Dahkki: Tomlinson, I, et al.
Almmustuhtton: (1996)

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Dahkki: Ricardo Mouro Pinto, et al.
Almmustuhtton: (2013-10-01)

Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro
Dahkki: Madelaine C. Brearley, et al.
Almmustuhtton: (2021-03-01)

Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1
Dahkki: Courtney, Eliza, et al.
Almmustuhtton: (2022)