MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

MYH associated polyposis is a hereditary syndrome responsible for early colorectal cancer with a distinct genetic pathway from the Familial Adenomatous Polyposis or the Hereditary Non Polyposis Colorectal Cancer syndrome. We have studied a family with three members bearing a biallelic mutation in MY...

Bibliografski detalji
Glavni autori:	Lefevre, J, Colas, C, Coulet, F, Bonilla, C, Mourra, N, Flejou, J, Tiret, E, Bodmer, W, Soubrier, F, Parc, Y
Format:	Journal article
Jezik:	English
Izdano:	2010

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od: Sieber, O, i dr.
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od: Skrzypczak Marzena, i dr.
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od: Wise Paul, i dr.
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Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
od: Wheeler, J, i dr.
Izdano: (1999)

Characterization of somatic mutations of colorectal tumor in a patient with concurrent APC and MLH1 germline mutations
od: Yunsheng Cheng, i dr.
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Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
od: Thirlwell, C, i dr.
Izdano: (2007)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.
od: Lefevre, J, i dr.
Izdano: (2012)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer
od: Lefevre, J, i dr.
Izdano: (2012)

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od: Karla L. Otterpohl, i dr.
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od: Dody Novrial, i dr.
Izdano: (2017-04-01)

The ABC of APC.
od: Fearnhead, N, i dr.
Izdano: (2001)

Intestinal Apc‐inactivation induces HSP25 dependency
od: Sanne M van Neerven, i dr.
Izdano: (2022-11-01)

Investigation of APC, MLH1 and MSH2 Mutations in Patients with Hereditary Colorectal Carcinoma: A Single Center Experience
od: Mehmet Buğrahan Düz
Izdano: (2021-01-01)

Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer.
od: Vania Myralda Giamour Marbun, i dr.
Izdano: (2022-01-01)

Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer
od: Vania Myralda Giamour Marbun, i dr.
Izdano: (2022-01-01)

rSNP_Guide-BASED EVALUATION OF SNPs IN PROMOTеRS OF THE HUMAN APC AND MLH1 GENES ASSOCIATED WITH COLON CANCER
od: D. A. Rasskazov, i dr.
Izdano: (2015-01-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
od: Bodmer, W
Izdano: (1999)

EBV-Infection in Cardiac and Non-Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1
od: Helene Geddert, i dr.
Izdano: (2010-01-01)

Mutations in <it>APC</it>, <it>CTNNB1 </it>and <it>K-ras </it>genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study
od: de Bruïne Adriaan P, i dr.
Izdano: (2005-12-01)

PHYSICAL MAPPING OF THE APC REGION
od: Thomas, H, i dr.
Izdano: (1991)

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od: Shen Yang, i dr.
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The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers.
od: Wheeler, J, i dr.
Izdano: (2000)

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
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The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI plus sporadic colorectal cancers
od: Wheeler, J, i dr.
Izdano: (2000)

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus sporadic RER plus colorectal cancers
od: Wheeler, J, i dr.
Izdano: (2000)

Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
od: Vid Leko, i dr.
Izdano: (2013-01-01)

MYH9 nephropathy
od: Taehoon Oh, i dr.
Izdano: (2015-03-01)

A case of MYH7 and MYH9 genes variants with cardiomyopathy and macrothrombocytopenia
od: Yasuhiro Ikawa, i dr.
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Nonmuscle myosin 2 proteins encoded by Myh9, Myh10, and Myh14 are uniquely distributed in the tubular segments of murine kidney
od: Karla L. Otterpohl, i dr.
Izdano: (2017-12-01)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.
od: Bonilla, C, i dr.
Izdano: (2011)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients
od: Bonilla, C, i dr.
Izdano: (2015)

APC in the regulation of intestinal crypt fission.
od: Wasan, H, i dr.
Izdano: (1998)

<it>MSH2 </it>and <it>MLH1 </it>testing
od: Kurzawski Grzegorz, i dr.
Izdano: (2008-06-01)

Assessing pathogenicity of <it>MLH1 </it>variants by co-expression of human <it>MLH1 </it>and <it>PMS2 </it>genes in yeast
od: Hudler Petra, i dr.
Izdano: (2009-10-01)

APC mutations are sufficient for the growth of early colorectal adenomas.
od: Lamlum, H, i dr.
Izdano: (2000)

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
od: Tomlinson, I, i dr.
Izdano: (1996)

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
od: Ricardo Mouro Pinto, i dr.
Izdano: (2013-10-01)

Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro
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Izdano: (2021-03-01)

Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1
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