Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

The leading malaria vaccine in development is the circumsporozoite (CS) protein-based vaccine, RTS,S, which targets the pre-erythrocytic stage of Plasmodium falciparum infection. It induces modest levels of protective efficacy largely mediated by CS specific antibodies. We aimed to enhance vaccine e...

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Bibliographic Details
Main Authors: Gilbert, S, Collins, K, Snaith, R, Cottingham, M, Hill, A
Format: Journal article
Published: Nature Publishing Group 2017