HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeosta...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Drakesmith, H, Chen, N, Ledermann, H, Screaton, G, Townsend, A, Xu, X
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2005

Παρόμοια τεκμήρια

The hemochromatosis protein HFE inhibits iron export from macrophages.
ανά: Drakesmith, H, κ.ά.
Έκδοση: (2002)

Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis
ανά: CAROLINE A ENNS
Έκδοση: (2006-01-01)

HFE Related Hemochromatosis: Uncovering the Inextricable Link between Iron Homeostasis and the Immunological System
ανά: Graça Porto, κ.ά.
Έκδοση: (2019-08-01)

Diabetes in HFE Hemochromatosis
ανά: James C. Barton, κ.ά.
Έκδοση: (2017-01-01)

Non-HFE hemochromatosis
ανά: Paulo Caleb Júnior de Lima Santos, κ.ά.
Έκδοση: (2012-01-01)

Molecular basis of HFE-hemochromatosis
ανά: Maja eVujic Spasic
Έκδοση: (2014-03-01)

HIV-1 down-regulates the expression of CD1d via Nef.
ανά: Chen, N, κ.ά.
Έκδοση: (2006)

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload.
ανά: Townsend, A, κ.ά.
Έκδοση: (2002)

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload
ανά: Townsend, A, κ.ά.
Έκδοση: (2002)

The structure and function of HFE.
ανά: Drakesmith, H, κ.ά.
Έκδοση: (2000)

Analysis of HFE and non-HFE gene mutations in Brazilian patients with hemochromatosis
ανά: Paulo Lisboa Bittencourt, κ.ά.
Έκδοση: (2009-01-01)

HFE hemochromatosis: an overview about therapeutic recommendations
ανά: Rodolfo D. Cancado, κ.ά.
Έκδοση: (2022-01-01)

Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
ανά: Wenke Moris, κ.ά.
Έκδοση: (2021-05-01)

Erratum: Role of HFE in iron metabolism, hereditary haemochomatosis, anaemia of chronic disease and secondary iron overload (Lancet (March 2) (786))
ανά: Townsend, A, κ.ά.
Έκδοση: (2002)

Role of HFE in iron metabolism, hereditary haemochomatosis, anaemia of chronic disease, and secondary iron overload (vol 359, pg 786, 2002)
ανά: Townsend, A, κ.ά.
Έκδοση: (2002)

Hemochromatosis gene (HFE) mutations in South East Asia: a potential for iron overload.
ανά: Pointon, J, κ.ά.
Έκδοση: (2003)

Despite Genetic Iron Overload, Hfe‐Hemochromatosis Mice Do Not Show Bone Loss
ανά: Alessa Wagner, κ.ά.
Έκδοση: (2019-09-01)

Homozygous deletion of HFE is the common cause of hemochromatosis in Sardinia
ανά: Gérald Le Gac, κ.ά.
Έκδοση: (2010-04-01)

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis
ανά: Domenico Girelli, κ.ά.
Έκδοση: (2011-04-01)

Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
ανά: Justin Chin, κ.ά.
Έκδοση: (2019-12-01)

The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.
ανά: Guangqin Fan, κ.ά.
Έκδοση: (2014-01-01)

Iron as a Therapeutic Target in <i>HFE</i>-Related Hemochromatosis: Usual and Novel Aspects
ανά: Olivier Loréal, κ.ά.
Έκδοση: (2018-11-01)

Hemochromatosis (HFE) gene mutations in Brazilian chronic hemodialysis patients
ανά: F.V. Perícole, κ.ά.
Έκδοση: (2005-09-01)

Do pregnancies reduce iron overload in HFE hemochromatosis women? results from an observational prospective study
ανά: Virginie Scotet, κ.ά.
Έκδοση: (2018-02-01)

Iron overload phenotypes and HFE genotypes in white hemochromatosis and iron overload screening study participants without HFE p.C282Y/p.C282Y.
ανά: James C Barton, κ.ά.
Έκδοση: (2022-01-01)

Iron overload phenotypes and HFE genotypes in white hemochromatosis and iron overload screening study participants without HFE p.C282Y/p.C282Y
ανά: James C. Barton, κ.ά.
Έκδοση: (2022-01-01)

Investigating the dependency of HIV-1 replication in macrophages on cellular iron
ανά: Drakesmith, H, κ.ά.
Έκδοση: (2007)

Effect of Native American ancestry on iron-related phenotypes of Alabama hemochromatosis probands with <it>HFE </it>C282Y homozygosity
ανά: Barton Ellen H, κ.ά.
Έκδοση: (2006-03-01)

Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
ανά: Kamihara-Ting, Junne
Έκδοση: (2008)

Chronic hepatitis B in children carried out of the hemochromatosis gene HFE
ανά: F. I. Inoyatova, κ.ά.
Έκδοση: (2021-07-01)

Identification of novel non-HFE mutations in Chinese patients with hereditary hemochromatosis
ανά: Wei Zhang, κ.ά.
Έκδοση: (2022-06-01)

Hereditary Hemochromatosis <it>(HFE) </it>genotypes in heart failure: Relation to etiology and prognosis
ανά: Torp-Pedersen Christian, κ.ά.
Έκδοση: (2010-07-01)

HFE-Related Hemochromatosis in a Chinese Patient: The First Reported Case
ανά: Wei Zhang, κ.ά.
Έκδοση: (2020-02-01)

Dietary Iron Overload and <i>Hfe<sup>−/−</sup></i> Related Hemochromatosis Alter Hepatic Mitochondrial Function
ανά: Christine Fischer, κ.ά.
Έκδοση: (2021-11-01)

Hfe Gene Knock-Out in a Mouse Model of Hereditary Hemochromatosis Affects Bodily Iron Isotope Compositions
ανά: Emmanuelle Albalat, κ.ά.
Έκδοση: (2021-10-01)

Clinical Manifestations of Hemochromatosis in HFE C282Y Homozygotes Identified by Screening
ανά: Gordon D McLaren, κ.ά.
Έκδοση: (2008-01-01)

Association of HFE genotypes with hemochromatosis-related phenotypes in the All of Us research program
ανά: Nandana D. Rao, κ.ά.
Έκδοση: (2025-01-01)

HFE Mutations in Caucasian Participants of the Hemochromatosis and Iron Overload Screening Study with Serum Ferritin Level <1000 μg/L
ανά: Paul C Adams, κ.ά.
Έκδοση: (2013-01-01)

Identification of new ligands for the haemochromatosis protein HFE
ανά: Drakesmith, H, κ.ά.
Έκδοση: (2007)

HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity
ανά: James C. Barton, κ.ά.
Έκδοση: (2022-06-01)