HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeosta...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Drakesmith, H, Chen, N, Ledermann, H, Screaton, G, Townsend, A, Xu, X
التنسيق: Journal article
اللغة:English
منشور في: 2005