Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing

<p><strong>Background:</strong>&nbsp;We previously demonstrated the in vitro killing of AML cells by the combination of the lipid-lowering agent bezafibrate (BEZ) and the contraceptive hormone medroxyprogesterone acetate (MPA). A phase II trial demonstrated in vivo safety and e...

Full description

Bibliographic Details
Main Authors: Jiang, Y, Southam, AD, Trova, S, Beke, F, Alhazmi, B, Francis, T, Radotra, A, di Maio, A, Drayson, MT, Bunce, CM, Khanim, FL
Format: Journal article
Language:English
Published: Springer Nature 2021