LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade
Chromatin regulators play a broad role in regulating gene expression and, when gone awry, can lead to cancer. Here, we demonstrate that ablation of the histone demethylase LSD1 in cancer cells increases repetitive element expression, including endogenous retroviral elements (ERVs), and decreases exp...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
Cell Press
2018
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