LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade

LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade

Chromatin regulators play a broad role in regulating gene expression and, when gone awry, can lead to cancer. Here, we demonstrate that ablation of the histone demethylase LSD1 in cancer cells increases repetitive element expression, including endogenous retroviral elements (ERVs), and decreases exp...

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Autors principals:	Sheng, W, LaFleur, MW, Nguyen, TH, Chen, S, Chakravarthy, A, Conway, JR, Li, Y, Chen, H, Yang, H, Hsu, P-H, Van Allen, EM, Freeman, GJ, De Carvalho, DD, He, HH, Sharpe, AH, Shi, Y
Format:	Journal article
Idioma:	English
Publicat:	Cell Press 2018

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