Self-assembly and evolution of homomeric protein complexes.
We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Physical Society
2009
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| _version_ | 1826306297060917248 |
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| author | Villar, G Wilber, A Williamson, A Thiara, P Doye, J Louis, A Jochum, M Lewis, A Levy, E |
| author_facet | Villar, G Wilber, A Williamson, A Thiara, P Doye, J Louis, A Jochum, M Lewis, A Levy, E |
| author_sort | Villar, G |
| collection | OXFORD |
| description | We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates. |
| first_indexed | 2024-03-07T06:45:49Z |
| format | Journal article |
| id | oxford-uuid:facf86d2-3e98-4f5f-9312-68d2b88851fb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:45:49Z |
| publishDate | 2009 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | oxford-uuid:facf86d2-3e98-4f5f-9312-68d2b88851fb2022-03-27T13:09:06ZSelf-assembly and evolution of homomeric protein complexes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:facf86d2-3e98-4f5f-9312-68d2b88851fbEnglishSymplectic Elements at OxfordAmerican Physical Society2009Villar, GWilber, AWilliamson, AThiara, PDoye, JLouis, AJochum, MLewis, ALevy, EWe introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates. |
| spellingShingle | Villar, G Wilber, A Williamson, A Thiara, P Doye, J Louis, A Jochum, M Lewis, A Levy, E Self-assembly and evolution of homomeric protein complexes. |
| title | Self-assembly and evolution of homomeric protein complexes. |
| title_full | Self-assembly and evolution of homomeric protein complexes. |
| title_fullStr | Self-assembly and evolution of homomeric protein complexes. |
| title_full_unstemmed | Self-assembly and evolution of homomeric protein complexes. |
| title_short | Self-assembly and evolution of homomeric protein complexes. |
| title_sort | self assembly and evolution of homomeric protein complexes |
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