Exploiting replication stress induced by IGF blockade in cancer therapy
<p>In recent work from our group, we found that genetic or pharmacological inhibition of type 1 insulin-like growth factor receptor (IGF-1R) promotes accumulation of cells in S phase and causes endogenous DNA damage by inducing replication stress. Blocking IGF signalling reduces expression of...
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| Format: | Disertacija |
| Jezik: | English |
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2020
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