The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis.

BACKGROUND: To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role in cancer. METHODS: Four snoRNAs, commonly used for normalisation, RNU44, RNU48, RNU43 and RNU6B, and miRNA known to be associated w...

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Detalles Bibliográficos
Main Authors: Gee, H, Buffa, F, Camps, C, Ramachandran, A, Leek, R, Taylor, M, Patil, M, Sheldon, H, Betts, G, Homer, J, West, C, Ragoussis, J, Harris, A
Formato: Journal article
Idioma:English
Publicado: 2011