A humanized monovalent CD3 antibody which can activate homologous complement.
The rat monoclonal antibody (mAb) YTH12.5, specific for the CD3 antigen complex on human T cells has been modified in order to improve its efficacy in human therapy. With the aim of rendering it less immunogenic, it has been humanized using the method of framework grafting. During this process seque...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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