Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

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INTRODUCTION: Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. METHODS: Immunop...

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Bibliographic Details
Main Authors: Yan, M, Jene, N, Byrne, D, Millar, E, O'Toole, SA, McNeil, C, Bates, G, Harris, A, Banham, A, Sutherland, R, Fox, S
Format: Journal article
Language:English
Published: 2011

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