Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.
We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations se...
| Hoofdauteurs: | , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
2001
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| _version_ | 1826306420976386048 |
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| author | Lennerstrand, J Stammers, D Larder, B |
| author_facet | Lennerstrand, J Stammers, D Larder, B |
| author_sort | Lennerstrand, J |
| collection | OXFORD |
| description | We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved in an ATP-dependent resistance mechanism analogous to pyrophosphorolysis, whereas the mechanism for RT with the Q151M or V75T mutation appears to be independent of added ATP for reducing binding to d4T-triphosphate. |
| first_indexed | 2024-03-07T06:47:43Z |
| format | Journal article |
| id | oxford-uuid:fb6cd7fd-57fe-4f4f-99ac-104c88a03c3d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:47:43Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:fb6cd7fd-57fe-4f4f-99ac-104c88a03c3d2022-03-27T13:13:43ZBiochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fb6cd7fd-57fe-4f4f-99ac-104c88a03c3dEnglishSymplectic Elements at Oxford2001Lennerstrand, JStammers, DLarder, BWe have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved in an ATP-dependent resistance mechanism analogous to pyrophosphorolysis, whereas the mechanism for RT with the Q151M or V75T mutation appears to be independent of added ATP for reducing binding to d4T-triphosphate. |
| spellingShingle | Lennerstrand, J Stammers, D Larder, B Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine. |
| title | Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine. |
| title_full | Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine. |
| title_fullStr | Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine. |
| title_full_unstemmed | Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine. |
| title_short | Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine. |
| title_sort | biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine |
| work_keys_str_mv | AT lennerstrandj biochemicalmechanismofhumanimmunodeficiencyvirustype1reversetranscriptaseresistancetostavudine AT stammersd biochemicalmechanismofhumanimmunodeficiencyvirustype1reversetranscriptaseresistancetostavudine AT larderb biochemicalmechanismofhumanimmunodeficiencyvirustype1reversetranscriptaseresistancetostavudine |