Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.

Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.

We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations se...

Bibliográfalaš dieđut
Váldodahkkit:	Lennerstrand, J, Stammers, D, Larder, B
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2001

Geahča maid

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Formation of heterodimers of human-immunodeficiency-virus-type-1 reverse transcriptase by recombination of separately purified subunits.
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Dahkki: Snowden, W, et al.
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Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.
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HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
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The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
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Structural characterization of HIV reverse transcriptase: a target for the design of specific virus inhibitors.
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Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase.
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Human Immunodeficiency Virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells
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Drug resistance in human immunodeficiency virus type-1 infected Zambian children using adult fixed dose combination stavudine, lamivudine, and nevirapine.
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HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis.
Dahkki: Lowe, D, et al.
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Revealing the Mutation Patterns of Drug-Resistant Reverse Transcriptase Variants of Human Immunodeficiency Virus through Proteochemometric Modeling
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Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors
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Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance.
Dahkki: Conlon, C, et al.
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Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.
Dahkki: Esnouf, R, et al.
Almmustuhtton: (1995)

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.
Dahkki: Ren, J, et al.
Almmustuhtton: (1998)

Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors.
Dahkki: Shafer, R, et al.
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New drug resistance mutations of reverse transcriptase Human immunodeficiency virus type-1 gene in first-line antiretroviral-infected patients in West Sumatra, Indonesia
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Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms
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The y271 and i274 amino acids in reverse transcriptase of human immunodeficiency virus-1 are critical to protein stability.
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Mutations in the Reverse Transcriptase and Protease Genes of Human Immunodeficiency Virus-1 from Antiretroviral Naïve and Treated Pediatric Patients
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A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781.
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Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)
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Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.
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Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.
Dahkki: Ren, J, et al.
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Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
Dahkki: Ren, J, et al.
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Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Dahkki: Ren, J, et al.
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Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease
Dahkki: Smeulders Liesbeth, et al.
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Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Dahkki: Ren, J, et al.
Almmustuhtton: (2000)

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
Dahkki: Hopkins, A, et al.
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HIV REVERSE-TRANSCRIPTASE MUTATION ENABLES EVASION OF CTL MEDIATED IMMUNITY
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