Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Показать другие версии (1)

Ferrous ion and 2-oxoglutarate (2OG) oxygenases catalyze the demethylation of N(epsilon)-methylated lysine residues in histones. Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dynamic combin...

Полное описание

Библиографические подробности
Главные авторы:	Rose, N, Woon, E, Kingham, G, King, O, Mecinović, J, Clifton, I, Ng, S, Talib-Hardy, J, Oppermann, U, McDonough, M, Schofield, C
Формат:	Journal article
Язык:	English
Опубликовано:	2010
Предметы:	Binding, Competitive Spectrometry, Mass, Electrospray Ionization Binding Sites analogs and derivatives chemistry Tyrosine Structure-Activity Relationship Crystallography, X-Ray chemical synthesis Models, Molecular Combinatorial Chemistry Techniques Oxalic Acids antagonists and inhibitors Jumonji Domain-Containing Histone Demethylases Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Схожие документы

A targeted mass spectrometric analysis of phosphatidylinositol phosphate species
по: Stephen B. Milne, и др.
Опубликовано: (2005-08-01)

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
по: Rose, N, и др.
Опубликовано: (2010)

Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples
по: Xianlin Han, и др.
Опубликовано: (2006-04-01)

Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals
по: Manman Qin, и др.
Опубликовано: (2023-01-01)

Investigating the regulation of membrane protein assemblies by lipids and other small molecules using native mass spectrometry
по: Shutin, D
Опубликовано: (2020)

Protein phosphorylation analysis by electrospray mass spectrometry : a guide to concepts and practice /
по: 507924 Lehmann, Wolf D.
Опубликовано: (2011)

Chemical reactivity hazard training [electronic resource] /
Опубликовано: (2006)

Espectrometria de massas com ionização por "electrospray": processos químicos envolvidos na formação de íons de substâncias orgânicas de baixo peso molecular
по: Crotti Antônio Eduardo Miller, и др.
Опубликовано: (2006-01-01)

Study on the Structural Effect of Maltoligosaccharides on Cytochrome c Complexes Stabilities by Native Mass Spectrometry
по: Quan Chi, и др.
Опубликовано: (2018-01-01)

Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis
по: Jiafa Zeng, и др.
Опубликовано: (2022-02-01)

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice
по: Keiko Tadano-Aritomi, и др.
Опубликовано: (2003-09-01)

A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A
по: Andrew J. Norris, и др.
Опубликовано: (2005-10-01)

Characterization of Nucleosides and Nucleobases in Natural Cordyceps by HILIC–ESI/TOF/MS and HILIC–ESI/MS
по: Bin Yang, и др.
Опубликовано: (2013-08-01)

Detection of Plasmodium vivax in a child returning from India by use of broad-range PCR and electrospray ionization mass spectrometry
по: Megan A Rounds, и др.
Опубликовано: (2012-07-01)

Estudo por espectrometria de massas de soluções de hidróxi(tosilóxi)iodobenzeno: propostas para mecanismos de desproporção
по: Ramon S. Vasconcelos, и др.
Опубликовано: (2012-01-01)

Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli
по: Teresa A. Garrett, и др.
Опубликовано: (2009-08-01)

Copper complexes formed by 3,5-bis(2,2′-bipyridin-4-ylethynyl)benzoic acid and its methyl and ethyl esters as studied by electrospray ionization mass spectrometry
по: Frański Rafał, и др.
Опубликовано: (2013-12-01)

Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
по: G. Liebisch, и др.
Опубликовано: (1999-08-01)

ESI-MS spectra of 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)-pyridinones
по: BRATISLAV Ž. JOVANOVIĆ, и др.
Опубликовано: (2009-03-01)

Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells
по: Anthony D. Postle, и др.
Опубликовано: (2006-06-01)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
по: Sakurai, M, и др.
Опубликовано: (2010)

Electrospray ionization mass spectrometric study of mercury complexes of N-heterocyclic carbenes derived from 1,2,4-triazolium salt precursors
по: Frański Rafał, и др.
Опубликовано: (2007-03-01)

DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid[S]
по: Hongbin Xu, и др.
Опубликовано: (2019-01-01)

Structural Characterization of Flavonoid Glycoconjugates and Their Derivatives with Mass Spectrometric Techniques
по: Piotr Kachlicki, и др.
Опубликовано: (2016-11-01)

Identification of Endocrine-Disrupting Compounds Using Nanoelectrospray Ionization Mass Spectrometry
по: Cédric Bovet, и др.
Опубликовано: (2008-05-01)

Moderate Signal Enhancement in Electrospray Ionization Mass Spectrometry by Focusing Electrospray Plume with a Dielectric Layer around the Mass Spectrometer’s Orifice
по: Zi Qing Chua, и др.
Опубликовано: (2024-01-01)

Preparing Apigenin from Leaves of Adinandra nitida
по: Zhengxiang Ning, и др.
Опубликовано: (2008-01-01)

Comment on Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an <i>Achillea millefolium</i> L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against <i>Helicobacter pylori</i>. <i>Antioxidants</i> 2022, <i>11</i>, 1849
по: Rafał Frański, и др.
Опубликовано: (2023-06-01)

Analytical Performance Evaluation of New DESI Enhancements for Targeted Drug Quantification in Tissue Sections
по: Margaux Fresnais, и др.
Опубликовано: (2022-06-01)

Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics
по: Kui Yang, и др.
Опубликовано: (2011-11-01)

Recent advancements in nanoelectrospray ionization interface and coupled devices
по: Shiyi Chen, и др.
Опубликовано: (2022-11-01)

Fabricating an Electrospray Ionization Chip Based on Induced Polarization and Liquid Splitting
по: Lvhan Zhou, и др.
Опубликовано: (2021-08-01)

Chromium interaction with O-donor humic-like ligands using electrospray-ionization mass spectrometry
по: Anđelković Darko H., и др.
Опубликовано: (2013-01-01)

Overcharging Effect in Electrospray Ionization Mass Spectra of Daunomycin-Tuftsin Bioconjugates
по: Lilla Pethő, и др.
Опубликовано: (2019-08-01)

Toward Depth-Resolved Analysis of Plant Metabolites by Nanospray Desorption Electrospray Ionization Mass Spectrometry
по: Sangwon Cha, и др.
Опубликовано: (2022-11-01)

Examining Interactions of Uranyl(VI) Ions with Amino Acids in the Gas Phase
по: Ana F. Lucena, и др.
Опубликовано: (2023-03-01)

Detecting Intermediates and Products of Fast Heterogeneous Reactions on Liquid Surfaces via Online Mass Spectrometry
по: Agustín J. Colussi, и др.
Опубликовано: (2019-01-01)

Electrospray mass spectrometry of human hair wax esters
по: Fitzgerald Mark, и др.
Опубликовано: (2007-05-01)

Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization
по: Xianlin Han, и др.
Опубликовано: (2005-07-01)

Ambient ionization mass spectrometry /
по: Cody, Robert, и др.
Опубликовано: (2015)