p53 methylation--the Arg-ument is clear.

p53 Activity is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumors have defective or inactive p53. In normal cells, p53 is held at low levels in a latent form and, following DNA damage, is stabilized which usually results in apopto...

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Bibliographic Details
Main Authors: Durant, S, Cho, E, La Thangue, N
Format: Journal article
Language:English
Published: 2009