Use of methods for specifying the target difference in randomised controlled trial sample size calculations: Two surveys of trialists' practice.

BACKGROUND: Central to the design of a randomised controlled trial (RCT) is a calculation of the number of participants needed. This is typically achieved by specifying a target difference, which enables the trial to identify a difference of a particular magnitude should one exist. Seven methods hav...

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Bibliographic Details
Main Authors: Cook, J, Hislop, J, Altman, D, Briggs, A, Fayers, P, Norrie, J, Ramsay, C, Harvey, I, Vale, L
Format: Journal article
Language:English
Published: SAGE Publications 2014